Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYN | P07948 | 1/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258067 | 0.90 | LYN (0.77) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13798003 | 0.80 | LYN (0.78) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL3256057 | 0.80 | LYN (0.77) | LYNMAPK9MAPK14MAPTKDM4E | |
| SCHEMBL13797965 | 0.79 | LYN (0.84) | LYNMAPK9MAPK14BRAFGSK3A | |
| SCHEMBL13359264 | 0.79 | LYN (0.59) | LYNMAPK9MAPK14MAPTKDM4E | |
| SCHEMBL13797976 | 0.77 | LYN (0.80) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL3255234 | 0.77 | LYN (1.00) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL3255421 | 0.77 | LYN (0.60) | LYNMAPK9MAPK14MAPTKDM4E | |
| SCHEMBL13797963 | 0.77 | LYN (0.79) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL3257628 | 0.76 | LYN (0.72) | LYNMAPK9MAPK14MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |