Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYN | P07948 | 1/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359241 | 0.87 | LYN (0.55) | LYNMAPK9MAPK14KMT2AMEN1 | |
| SCHEMBL3256057 | 0.87 | LYN (0.77) | LYNMAPK9MAPK14KDRKDM4E | |
| SCHEMBL13359212 | 0.85 | LYN (0.51) | LYNMAPK9MAPK14RAB9AALDH1A1 | |
| SCHEMBL3255421 | 0.82 | LYN (0.60) | LYNMAPK9MAPK14KDRKDM4E | |
| SCHEMBL3257419 | 0.80 | KDR (0.55) | LYNMAPK9KDRKDM4EMAPK1 | |
| SCHEMBL13359206 | 0.79 | LYN (0.62) | LYNMAPK9MAPK14KDM4EKMT2A | |
| SCHEMBL13359286 | 0.79 | MAPK14 (0.49) | LYNMAPK9MAPK14MAPK1RAB9A | |
| SCHEMBL13798003 | 0.78 | LYN (0.78) | LYNMAPK9MAPK14 | |
| SCHEMBL13359163 | 0.78 | ALDH1A1 (0.42) | LYNMAPK9MAPK14KDM4EMAPK1 | |
| SCHEMBL13359141 | 0.78 | LYN (0.45) | LYNMAPK9MAPK14KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |