Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13271789 | 0.85 | ATM (0.37) | ATMESR2MAPK1GPR119HDAC1 | |
| SCHEMBL13329601 | 0.83 | ADORA1 (0.41) | ATMMAPK1GPR119GLSTSHR | |
| SCHEMBL13271560 | 0.76 | GPR119 (0.48) | ESR2GPR119HDAC1HDAC6GLS | |
| SCHEMBL13329617 | 0.75 | NPY2R (0.41) | ATMMAPK1GLSTSHRMEN1 | |
| SCHEMBL13250469 | 0.73 | NPY2R (0.41) | ATMMAPK1TSHRMEN1KMT2A | |
| SCHEMBL13360730 | 0.72 | ESR2 (0.50) | ESR2MAPK1NR1H2KDM4E | |
| SCHEMBL13271559 | 0.70 | ADORA1 (0.47) | ESR2MAPK1NR1H2KDM4E | |
| SCHEMBL21047249 | 0.69 | ADORA1 (0.43) | ATMESR2GPR119GLSTSHR | |
| SCHEMBL1219803 | 0.69 | ADORA1 (0.43) | ATMESR2GPR119GLSTSHR | |
| SCHEMBL1219800 | 0.69 | ADORA1 (0.43) | ATMESR2GPR119GLSTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130584-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |