Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | MPL | P40238 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 11/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 11/20 | 0.38 |
| ▸ | ITGAL | P20701 | 11/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.37 |
| ▸ | AKT1 | P31749 | 3/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12242032 | 0.89 | KDR (0.37) | MPLAKT1MALT1KDM4EALDH1A1 | |
| SCHEMBL12242027 | 0.86 | KDM4E (0.38) | MALT1KDM4EALDH1A1LMNA | |
| SCHEMBL12242030 | 0.86 | PIM2 (0.39) | KMOGSK3BITGB2ICAM1ITGAL | |
| SCHEMBL12242035 | 0.85 | MPL (0.42) | MPLKDM4EALDH1A1LMNA | |
| SCHEMBL12242042 | 0.85 | JAK2 (0.44) | MAPK14RPS6KB1KDM4EALDH1A1LMNA | |
| SCHEMBL12242103 | 0.85 | LMNA (0.44) | KMOKDM4EALDH1A1LMNA | |
| SCHEMBL12242021 | 0.84 | LMNA (0.39) | MAPK14KDM4EALDH1A1LMNA | |
| SCHEMBL12242024 | 0.84 | LMNA (0.43) | MAPK14KDM4EALDH1A1LMNA | |
| SCHEMBL12242022 | 0.84 | KDM4E (0.45) | MAPK14KDM4EALDH1A1LMNA | |
| SCHEMBL12242029 | 0.83 | PDE4A (0.41) | GSK3BMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056549-A1 | PYRIDINE, BICYCLIC PYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | disclosed |