SCHEMBL13367223

SCHEMBL13367223

CCCCOc1c(C(=O)N2CCSC2=S)cc(C)n(Cc2ccccc2)c1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.43
ALDH1A1 P00352 6/20 0.43
MAPT P10636 5/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
CYP1A2 P05177 1/20 0.42
CYP2C19 P33261 1/20 0.42
TSHR P16473 3/20 0.40
NOTUM Q6P988 1/20 0.39
HSD17B10 Q99714 1/20 0.38
S1PR2 O95136 1/20 0.37
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
MAPK1 P28482 2/20 0.36
USP2 O75604 1/20 0.36
GAA P10253 1/20 0.36
MEN1 O00255 2/20 0.35
THRB P10828 2/20 0.34
LMNA P02545 1/20 0.34
TP53 P04637 1/20 0.34
KLK1 P06870 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3424491 0.90 ALDH1A1 (0.44) KMT2AALDH1A1MAPTSMN1; SMN2CYP1A2
SCHEMBL17980871 0.85 MAPT (0.43) KMT2AALDH1A1MAPTSMN1; SMN2CYP1A2
SCHEMBL17972806 0.81 ALDH1A1 (0.42) KMT2AALDH1A1MAPTSMN1; SMN2CYP1A2
SCHEMBL19057300 0.81 MAPT (0.39) KMT2AALDH1A1MAPTSMN1; SMN2CYP1A2
SCHEMBL13367222 0.80 NOTUM (0.56) KMT2AALDH1A1MAPTSMN1; SMN2TSHR
SCHEMBL13367221 0.78 TSHR (0.63) KMT2AALDH1A1MAPTSMN1; SMN2TSHR
SCHEMBL17980841 0.77 MAPT (0.56) KMT2AALDH1A1MAPTSMN1; SMN2CYP1A2
SCHEMBL19050886 0.77 ALDH1A1 (0.38) KMT2AALDH1A1MAPTSMN1; SMN2CYP1A2
SCHEMBL12697310 0.77 MAPT (0.58) KMT2AALDH1A1MAPTSMN1; SMN2CYP1A2
SCHEMBL13952961 0.76 MAPT (0.58) KMT2AALDH1A1MAPTSMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7718781-B2 Hydroxypyridonate and hydroxypyrimidinone chelating agents THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-05-18 US disclosed
WO-2007121453-A2 2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-10-25 WO disclosed