SCHEMBL13367285

SCHEMBL13367285

CCCCOc1c(C(=O)NCCN(CCNC(=O)c2ccn(C)c(=O)c2OCCCC)CCNC(=O)c2ccn(C)c(=O)c2OCCCC)ccc(C(=O)N2CCSC2=S)c1OCCCC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.39
MAPT P10636 6/20 0.39
KMT2A Q03164 6/20 0.39
SMN1; SMN2 Q16637 4/20 0.39
GAA P10253 3/20 0.34
KDM4E B2RXH2 2/20 0.34
CYP1A2 P05177 2/20 0.34
ABCB11 O95342 1/20 0.34
LMNA P02545 1/20 0.34
CYP2D6 P10635 1/20 0.34
HPGD P15428 1/20 0.34
SCN1A P35498 1/20 0.34
OPRK1 P41145 1/20 0.34
KCNH2 Q12809 1/20 0.34
CACNA1C Q13936 1/20 0.34
SCN5A Q14524 1/20 0.34
GHSR Q92847 1/20 0.34
SCN2A Q99250 1/20 0.34
SCN3A Q9NY46 1/20 0.34
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19057297 0.92 ALDH1A1 (0.46) ALDH1A1MAPTKMT2ASMN1; SMN2GAA
SCHEMBL19057230 0.91 ALDH1A1 (0.47) ALDH1A1MAPTKMT2ASMN1; SMN2GAA
SCHEMBL13339932 0.87 SMN1; SMN2 (0.37) ALDH1A1MAPTKMT2ASMN1; SMN2GAA
SCHEMBL13367283 0.87 ALDH1A1 (0.50) ALDH1A1MAPTKMT2ASMN1; SMN2CYP1A2
SCHEMBL19057228 0.86 ALDH1A1 (0.46) ALDH1A1MAPTKMT2ASMN1; SMN2GAA
SCHEMBL17980866 0.85 ALDH1A1 (0.41) ALDH1A1MAPTKMT2ASMN1; SMN2GAA
SCHEMBL15613436 0.85 MAPT (0.50) ALDH1A1MAPTKMT2ASMN1; SMN2CYP1A2
SCHEMBL15613407 0.85 ALDH1A1 (0.40) ALDH1A1MAPTKMT2ASMN1; SMN2GAA
SCHEMBL17981704 0.83 ALDH1A1 (0.42) ALDH1A1MAPTKMT2ASMN1; SMN2GAA
SCHEMBL15613424 0.83 MAPT (0.47) ALDH1A1MAPTKMT2ASMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7718781-B2 Hydroxypyridonate and hydroxypyrimidinone chelating agents THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-05-18 US disclosed
WO-2007121453-A2 2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-10-25 WO disclosed