Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13341279 | 0.93 | AURKA (0.44) | AURKAAURKBRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2488708 | 0.87 | AURKA (0.40) | AURKAAURKBRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2511374 | 0.86 | AURKA (0.43) | AURKAAURKBRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2492165 | 0.86 | AURKA (0.43) | AURKAAURKBRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2488713 | 0.86 | AURKA (0.43) | AURKAAURKBRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2488719 | 0.86 | AURKA (0.43) | AURKAAURKBRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL3424599 | 0.85 | HDAC1 (0.41) | AURKAAURKBRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL13341319 | 0.84 | HDAC6 (0.45) | AURKAAURKBRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2486444 | 0.84 | MAPT (0.45) | AURKAAURKBRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL3426661 | 0.84 | RAB9A (0.48) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7714010-B2 | Pyrrolobenzimidazolones and their use as anti-proliferative agents | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-11 | — | — | US | disclosed |