Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.64 |
| ▸ | KIT | P10721 | 13/20 | 0.53 |
| ▸ | FLT3 | P36888 | 13/20 | 0.53 |
| ▸ | CSF1R | P07333 | 8/20 | 0.43 |
| ▸ | FLT1 | P17948 | 8/20 | 0.43 |
| ▸ | LYN | P07948 | 7/20 | 0.43 |
| ▸ | SRC | P12931 | 7/20 | 0.43 |
| ▸ | FLT4 | P35916 | 7/20 | 0.43 |
| ▸ | BLK | P51451 | 7/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | LTK | P29376 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740442 | 0.89 | KDR (0.81) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL28757594 | 0.87 | KDR (0.48) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL27636497 | 0.81 | KDR (0.52) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL13372669 | 0.78 | KDR (0.68) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL29923459 | 0.78 | KDR (1.00) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL1426417 | 0.78 | KDR (1.00) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL27657327 | 0.78 | KDR (0.62) | KDRKITFLT3CSF1RFLT1 | |
| Water SCHEMBL15475146 | 0.77 | KDR (0.98) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL27657443 | 0.76 | KDR (0.60) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL27636382 | 0.76 | KDR (0.60) | KDRKITFLT3CSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246333-B1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2012-10-24 | — | — | EP | disclosed |