Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.81 |
| ▸ | FLT3 | P36888 | 9/20 | 0.57 |
| ▸ | KIT | P10721 | 8/20 | 0.57 |
| ▸ | FLT1 | P17948 | 8/20 | 0.57 |
| ▸ | ABL1 | P00519 | 8/20 | 0.57 |
| ▸ | FLT4 | P35916 | 7/20 | 0.57 |
| ▸ | CSF1R | P07333 | 7/20 | 0.57 |
| ▸ | LYN | P07948 | 5/20 | 0.57 |
| ▸ | SRC | P12931 | 5/20 | 0.57 |
| ▸ | BLK | P51451 | 5/20 | 0.57 |
| ▸ | RET | P07949 | 4/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.57 |
| ▸ | PRKACA | P17612 | 4/20 | 0.57 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.57 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.57 |
| ▸ | PLK4 | O00444 | 3/20 | 0.57 |
| ▸ | AURKA | O14965 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1426417 | 0.90 | KDR (1.00) | KDRFLT3KITFLT1ABL1 | |
| SCHEMBL29923459 | 0.90 | KDR (1.00) | KDRFLT3KITFLT1ABL1 | |
| Water SCHEMBL15475146 | 0.89 | KDR (0.98) | KDRFLT3KITFLT1ABL1 | |
| SCHEMBL13372706 | 0.89 | KDR (0.64) | KDRFLT3KITFLT1ABL1 | |
| Alcohol SCHEMBL16817143 | 0.87 | KDR (0.94) | KDRFLT3KITFLT1ABL1 | |
| SCHEMBL27636400 | 0.87 | KDR (0.62) | KDRFLT3KITFLT1ABL1 | |
| SCHEMBL27636422 | 0.83 | KDR (0.64) | KDRFLT3KITFLT1ABL1 | |
| SCHEMBL27636446 | 0.83 | KDR (0.64) | KDRFLT3KITFLT1ABL1 | |
| SCHEMBL27657307 | 0.82 | KDR (0.66) | KDRFLT3KITFLT1ABL1 | |
| SCHEMBL28757592 | 0.81 | KDR (0.61) | KDRFLT3KITFLT1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008080110-A1 | METHODS FOR TREATING MACULAR EDEMA AND PATHOLOGIC OCULAR ANGIOGENESIS USING A NEUROPROTECTIVE AGENT AND A RECEPTOR TYROSINE KINASE INHIBITOR | ALCON, INC. (CH) | 2008-07-03 | — | — | WO | disclosed |