Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 4/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13373552 | 0.79 | MAPT (0.43) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL7216263 | 0.77 | MAPT (0.48) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL7220759 | 0.77 | MAPT (0.48) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL24192686 | 0.74 | PDE2A (0.42) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL22433010 | 0.72 | MAPT (0.50) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL2508937 | 0.72 | MAPT (0.50) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL24191926 | 0.71 | PDE2A (0.42) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL12388161 | 0.68 | MAPT (0.46) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL16710806 | 0.68 | MAPT (0.42) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL20954118 | 0.68 | EPHX1 (0.44) | MAPTKDM4EALDH1A1APEX1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |