Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 4/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.32 |
| ▸ | CDK1 | P06493 | 3/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13375188 | 0.95 | ABL1 (0.36) | ABL1SMN1; SMN2MEN1KMT2AAURKA | |
| SCHEMBL13375196 | 0.89 | ABL1 (0.37) | ABL1SMN1; SMN2KMT2AAURKAAURKB | |
| SCHEMBL13375327 | 0.88 | ABL1 (0.37) | ABL1SMN1; SMN2KMT2APDPK1KDM4E | |
| SCHEMBL5952165 | 0.86 | HSD17B10 (0.39) | ABL1ATRSMN1; SMN2AURKAAURKB | |
| SCHEMBL13375199 | 0.85 | SYK (0.39) | ABL1ITKSYK | |
| SCHEMBL3924807 | 0.83 | ATR (0.34) | ABL1ATRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3935602 | 0.83 | FLT3 (0.34) | ABL1ATRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13374026 | 0.81 | HSD17B10 (0.39) | ABL1ATRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13375054 | 0.81 | ABL1 (0.33) | ABL1 | |
| SCHEMBL3930653 | 0.80 | ABL1 (0.36) | ABL1ATRSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |