Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 15/20 | 0.65 |
| ▸ | ICOSLG | O75144 | 8/20 | 0.65 |
| ▸ | ICOS | Q9Y6W8 | 8/20 | 0.65 |
| ▸ | IKBKB | O14920 | 2/20 | 0.65 |
| ▸ | TYK2 | P29597 | 1/20 | 0.65 |
| ▸ | CLK1 | P49759 | 1/20 | 0.65 |
| ▸ | CLK2 | P49760 | 1/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.65 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14253077 | 0.91 | CHUK (0.67) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL12619360 | 0.88 | CHUK (0.68) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL14253080 | 0.86 | CHUK (0.69) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL2767580 | 0.86 | CHUK (0.74) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL13442718 | 0.83 | CHUK (0.65) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL13315615 | 0.83 | CHUK (0.69) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL13377085 | 0.82 | CHUK (0.66) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL2768231 | 0.79 | CHUK (0.78) | CHUKICOSLGICOSIKBKBMEN1 | |
| SCHEMBL1420073 | 0.79 | CHUK (1.00) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1801372 | 0.79 | ICOSLG (1.00) | CHUKICOSLGICOSIKBKBTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268477-B1 | SUBSTITUTED BETA-CARBOLINES WITH IKB-KINASE INHIBITING ACTIVITY | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-04-21 | — | — | EP | disclosed |
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |