Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 16/20 | 1.00 |
| ▸ | ICOSLG | O75144 | 9/20 | 1.00 |
| ▸ | ICOS | Q9Y6W8 | 9/20 | 1.00 |
| ▸ | IKBKB | O14920 | 2/20 | 1.00 |
| ▸ | TYK2 | P29597 | 1/20 | 1.00 |
| ▸ | CLK1 | P49759 | 1/20 | 1.00 |
| ▸ | CLK2 | P49760 | 1/20 | 1.00 |
| ▸ | DYRK1A | Q13627 | 1/20 | 1.00 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 1.00 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30039188 | 1.00 | CHUK (1.00) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL30492167 | 1.00 | CHUK (1.00) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL30342072 | 1.00 | CHUK (1.00) | CHUKICOSLGICOSIKBKBTYK2 | |
| Hydrochloric Acid SCHEMBL18114522 | 0.99 | CHUK (0.98) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1798941 | 0.91 | CHUK (0.84) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL17225471 | 0.90 | CHUK (0.81) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1801372 | 0.89 | ICOSLG (1.00) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL12653357 | 0.89 | CHUK (0.80) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1797398 | 0.87 | CHUK (0.77) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1803613 | 0.87 | CHUK (0.77) | CHUKICOSLGICOSIKBKBTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250082652-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | UNIVERSITÄT ZU KÖLN (DE) | 2025-03-13 | — | — | US | claimed |
| US-20250025542-A1 | COMPOSITIONS AND METHODS FOR INDUCING IMMUNE TOLERANCE | THE UNIVERSITY OF CHICAGO (US) | 2025-01-23 | — | — | US | claimed |
| EP-4460301-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | Universität zu Köln (DE) | 2024-11-13 | — | — | EP | claimed |
| US-20240325402-A1 | MOMELOTINIB COMBINATION THERAPY | SIERRA ONCOLOGY LLC | 2024-10-03 | — | — | US | claimed |
| EP-3720493-B1 | COMBINATIONS OF RIPK1- AND IKK-INHIBITORS FOR THE PREVENTION OR TREATMENT OF IMMUNE DISEASES | UNIV KOELN (DE) | 2024-07-24 | — | — | EP | claimed |
| CN-117794546-A | Molotinib combination therapy | 葛兰素史密斯克莱有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-115413669-B | Kinase inhibitor and application of composition thereof in improving bacterial wilt resistance of plants | 湖南大学 | 2024-03-15 | — | — | CN | claimed |
| WO-2023131576-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | UNIVERSITÄT ZU KÖLN (DE) | 2023-07-13 | — | — | WO | claimed |
| EP-4209213-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | Universität zu Köln (DE) | 2023-07-12 | — | — | EP | claimed |
| WO-2023086806-A1 | COMPOSITIONS AND METHODS FOR INDUCING IMMUNE TOLERANCE | THE UNIVERSITY OF CHICAGO (US) | 2023-05-19 | — | — | WO | claimed |
| CN-115413669-A | Application of kinase inhibitor and combined agent thereof in improving bacterial wilt resistance of plants | 湖南大学 | 2022-12-02 | — | — | CN | claimed |
| US-20220110953-A1 | METHODS AND COMPOSITIONS FOR TREATING HUMAN PAPILLOMAVIRUS (HPV)-INDUCED CANCERS | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2022-04-14 | — | — | US | claimed |
| US-10744141-B2 | Compositions and methods for treating cancer | CASE WESTERN RESERVE UNIVERSITY (US) | 2020-08-18 | — | — | US | claimed |
| US-20180185382-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | CASE WESTERN RESERVE UNIVERSITY | 2018-07-05 | — | — | US | claimed |
| EP-3313819-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | Case Western Reserve University (US) | 2018-05-02 | — | — | EP | claimed |
| WO-2017044940-A1 | CELL MEMBRANE-FORMED NANOSCALE VESICLES AND METHODS OF USING THEREOF | WASHINGTON STATE UNIVERSITY (US) | 2017-03-16 | — | — | WO | claimed |
| WO-2016210134-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-12-29 | — | — | WO | claimed |
| WO-2013052844-A1 | METHODS FOR TREATING AND DIAGNOSING RESPIRATORY TRACT INFECTIONS | PULMATRIX, INC. (US) | 2013-04-11 | — | — | WO | claimed |
| US-20260021108-A1 | USE OF INHIBITORS OF THE HIPPO SIGNALLING PATHWAY FOR THE TREATMENT OF CHRONIC NEPHROPATHIES | INST NAT SANTE RECH MED (FR) | 2026-01-22 | — | — | US | disclosed |
| WO-2004092167-A1 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240325402-A1 | MOMELOTINIB COMBINATION THERAPY | TPMT, ABL1, JAK1 | CHUK 28/4885ICOSLG 2318/4885ICOS 582/4885 |
| US-20180185382-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | PPP2CA, PPP3CA, PPP4C | CHUK 848/4885ICOSLG 4701/4885ICOS 4250/4885 |
| US-10744141-B2 | Compositions and methods for treating cancer | PPP2CA, PPP3CA, PPP4C | CHUK 848/4885ICOSLG 4701/4885ICOS 4250/4885 |
| US-20260021108-A1 | USE OF INHIBITORS OF THE HIPPO SIGNALLING PATHWAY FOR THE TREATMENT OF CHRONIC NEPHROPATHIES | MST1, LATS1, LATS2 | CHUK 306/4885ICOSLG 1466/4885ICOS 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.