Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1338074 | 0.90 | L3MBTL1 (0.40) | POLBPTPN11L3MBTL1NOTUMBRD4 | |
| SCHEMBL1339086 | 0.89 | L3MBTL1 (0.42) | POLBL3MBTL1NOTUMBRAFJAK2 | |
| SCHEMBL1338537 | 0.89 | L3MBTL1 (0.44) | L3MBTL1NOTUMBRAFJAK2ATR | |
| SCHEMBL1338390 | 0.88 | L3MBTL1 (0.43) | POLBPTPN11L3MBTL1NOTUMBRD4 | |
| SCHEMBL1338123 | 0.84 | L3MBTL1 (0.39) | POLBPTPN11L3MBTL1NOTUMPIM1 | |
| SCHEMBL1338786 | 0.82 | L3MBTL1 (0.50) | L3MBTL1NOTUM | |
| SCHEMBL1339283 | 0.81 | MAPK14 (0.43) | BRAFCYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL1337392 | 0.79 | HSD17B10 (0.46) | L3MBTL1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL4762650 | 0.78 | CYP3A4 (0.34) | POLBCYP3A4 | |
| SCHEMBL3866299 | 0.75 | HSD17B10 (0.44) | POLBL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063061-B2 | 6-(2-amino-1,3-thiazol-4-yl)-3-(2,4-dichlorophenyl)-1-methyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one; affinity for GABAA-receptor-associated omega modulatory sites | SANOFI-AVENTIS (FR) | 2011-11-22 | — | — | US | disclosed |
| EP-1940840-B1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-07-21 | — | — | EP | disclosed |