Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12389321 | 0.81 | HTR2B (0.44) | — | |
| SCHEMBL12389840 | 0.78 | MAPT (0.41) | MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL12389841 | 0.77 | LMNA (0.45) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL13384432 | 0.77 | AURKA (0.33) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL12365805 | 0.75 | MAPK14 (0.41) | HSP90AA1HSP90AB1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL12365045 | 0.75 | IGF1R (0.38) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL12389153 | 0.74 | MAPK14 (0.42) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL12365807 | 0.74 | MAPK14 (0.47) | MAPT | |
| SCHEMBL12365049 | 0.73 | LMNA (0.41) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL12389723 | 0.72 | LMNA (0.45) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177505-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-04-21 | — | — | EP | disclosed |