Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 12/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293153 | 0.81 | IMPDH2 (0.61) | IMPDH2SLC6A4XDH | |
| SCHEMBL22450677 | 0.79 | IMPDH2 (0.59) | IMPDH2SLC6A4XDH | |
| SCHEMBL16455429 | 0.79 | IMPDH2 (0.59) | IMPDH2SLC6A4XDH | |
| SCHEMBL7273946 | 0.79 | IMPDH2 (0.59) | IMPDH2SLC6A4XDHGSK3B | |
| SCHEMBL2417482 | 0.79 | IMPDH2 (0.59) | IMPDH2SLC6A4XDHGSK3B | |
| SCHEMBL1777994 | 0.77 | IMPDH2 (0.56) | IMPDH2SLC6A4GSK3B | |
| SCHEMBL16743115 | 0.77 | IMPDH2 (0.56) | IMPDH2SLC6A4XDH | |
| SCHEMBL24182135 | 0.76 | IMPDH2 (0.54) | IMPDH2SLC6A4XDHCHRNA7 | |
| SCHEMBL12523498 | 0.74 | GSK3B (0.40) | IMPDH2GSK3BCDK2CHRNA7 | |
| SCHEMBL1778037 | 0.74 | IMPDH2 (1.00) | IMPDH2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036613-A1 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME CORP. (US) | 2010-04-01 | — | — | WO | disclosed |