Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.58 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | INPPL1 | O15357 | 2/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005667 | 1.00 | MET (0.58) | METMAP4K3JAK2INPPL1ALK | |
| SCHEMBL1582121 | 0.87 | MET (0.66) | METMAP4K3JAK2INPPL1ALK | |
| SCHEMBL488720 | 0.87 | MET (0.66) | METMAP4K3JAK2INPPL1ALK | |
| SCHEMBL5486840 | 0.82 | MAP4K3 (0.62) | METMAP4K3JAK2INPPL1ALK | |
| SCHEMBL3123822 | 0.81 | MET (0.69) | METJAK2INPPL1 | |
| SCHEMBL31672489 | 0.81 | MET (0.69) | METJAK2INPPL1 | |
| SCHEMBL488414 | 0.81 | MAP4K3 (0.61) | METMAP4K3JAK2INPPL1 | |
| SCHEMBL30453935 | 0.81 | MAP4K3 (0.61) | METMAP4K3JAK2INPPL1 | |
| SCHEMBL28756989 | 0.80 | MET (0.60) | METMAP4K3JAK2 | |
| SCHEMBL27630152 | 0.80 | MAP4K3 (0.60) | METMAP4K3JAK2INPPL1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786785-B1 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-04-07 | — | — | EP | disclosed |