⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9908300 | 1.00 | — | — | |
| SCHEMBL17719389 | 0.93 | LMNA (0.30) | — | |
| SCHEMBL15502116 | 0.93 | LMNA (0.30) | — | |
| SCHEMBL10083636 | 0.83 | — | — | |
| SCHEMBL7638369 | 0.83 | — | — | |
| SCHEMBL13105445 | 0.81 | LMNA (0.38) | — | |
| SCHEMBL13909498 | 0.81 | LMNA (0.38) | — | |
| SCHEMBL14031628 | 0.81 | LMNA (0.38) | — | |
| SCHEMBL16432803 | 0.81 | LMNA (0.38) | — | |
| SCHEMBL13120129 | 0.81 | LMNA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127343-A1 | NOVEL COMPOUNDS FOR TREATING DIABETES | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2018-05-10 | — | — | US | disclosed |
| US-9914688-B2 | Optically pure benzyl-4-chlorophenyl-C-glucoside derivative | SIHUAN PHARMACEUTICAL HOLDINGS GROUP LTD. (CN) | 2018-03-13 | — | — | US | disclosed |
| US-20170247359-A1 | PROCESS FOR THE PREPARATION OF CANAGLIFLOZIN | MYLAN LABORATORIES LTD (IN) | 2017-08-31 | — | — | US | disclosed |
| US-20160194264-A1 | OPTICALLY PURE BENZYL-4-CHLOROPHENYL-C-GLUCOSIDE DERIVATIVE | Xuanzhu Pharma Co., Ltd. (CN) | 2016-07-07 | — | — | US | disclosed |
| US-9315438-B2 | Optically pure benzyl-4-chlorophenyl-C-glucoside derivative | XUANZHU PHARMA CO., LTD (CN) | 2016-04-19 | — | — | US | disclosed |
| US-20150191502-A1 | OPTICALLY PURE BENZYL-4-CHLOROPHENYL-C-GLUCOSIDE DERIVATIVE | Xuanzhu Pharma Co., Ltd. (CN) | 2015-07-09 | — | — | US | disclosed |
| US-9056850-B2 | Process for the preparation of compounds useful as inhibitors of SGLT | JANSSEN PHARMACEUTICA N.V. (BE) | 2015-06-16 | — | — | US | disclosed |
| US-9006187-B2 | Thiophene derivative as SGLT2 inhibitor and pharmaceutical composition comprising same | GREEN CROSS CORPORATION (KR) | 2015-04-14 | — | — | US | disclosed |
| US-20140274921-A1 | GLYCOSIDE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2014-09-18 | — | — | US | disclosed |
| US-20130172278-A1 | NOVEL THIOPHENE DERIVATIVE AS SGLT2 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | GREEN CROSS CORPORATION (KR) | 2013-07-04 | — | — | US | disclosed |
| US-8058245-B2 | Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2011-11-15 | — | — | US | disclosed |
| US-20100099883-A1 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-22 | — | — | US | disclosed |
| US-7419959-B2 | D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture | BOEHRINGER INGELHEIM INTERNATIONAL, GMBH (DE) | 2008-09-02 | — | — | US | disclosed |
| US-20070197450-A1 | Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof | KISSEI PHARMACEUTICAL CO., LTD. | 2007-08-23 | — | — | US | disclosed |