Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.59 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.59 |
| ▸ | LPAR2 | Q9HBW0 | 5/20 | 0.59 |
| ▸ | SAT1 | P21673 | 1/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5978775 | 0.94 | LPAR3 (0.62) | LPAR3LPAR1LPAR2SAT1S1PR2 | |
| SCHEMBL9320338 | 0.92 | LPAR3 (0.66) | LPAR3LPAR1LPAR2SAT1S1PR2 | |
| SCHEMBL7108271 | 0.92 | LPAR3 (0.66) | LPAR3LPAR1LPAR2SAT1S1PR2 | |
| SCHEMBL27788145 | 0.92 | LPAR3 (0.66) | LPAR3LPAR1LPAR2SAT1S1PR2 | |
| SCHEMBL13400487 | 0.92 | LPAR3 (0.64) | LPAR3LPAR1LPAR2SAT1S1PR2 | |
| SCHEMBL31325193 | 0.89 | LPAR3 (0.78) | LPAR3LPAR1LPAR2SAT1S1PR2 | |
| SCHEMBL31325198 | 0.89 | LPAR3 (0.78) | LPAR3LPAR1LPAR2SAT1S1PR2 | |
| SCHEMBL31325188 | 0.89 | LPAR3 (0.78) | LPAR3LPAR1LPAR2SAT1S1PR2 | |
| SCHEMBL6528738 | 0.88 | LPAR3 (0.52) | LPAR3LPAR1LPAR2SAT1S1PR2 | |
| SCHEMBL17859165 | 0.85 | LPAR3 (0.44) | LPAR3LPAR1LPAR2SAT1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567358-B2 | Methods of treatment using N-(3-fluorophenyl)-2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-quinazolin-4-yl)amino]-1H-pyrazol-5-yl}acetamide | ASTRAZENECA AB (SE) | 2017-02-14 | — | — | US | disclosed |
| US-7691867-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2010-04-06 | — | — | US | disclosed |