Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.49 |
| ▸ | GCGR | P47871 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485683 | 0.83 | NR1I2 (0.74) | NR1I2CACNA1B | |
| SCHEMBL13401204 | 0.83 | SERPINE1 (0.41) | NR1I2PTGS2CACNA1BGCGR | |
| SCHEMBL8152069 | 0.82 | CACNA1B (0.59) | NR1I2CACNA1B | |
| SCHEMBL8156765 | 0.80 | CACNA1B (0.75) | NR1I2CACNA1B | |
| SCHEMBL8151113 | 0.75 | NR1I2 (0.61) | NR1I2CACNA1B | |
| SCHEMBL8150104 | 0.74 | NR1I2 (0.73) | NR1I2CACNA1B | |
| SCHEMBL8150555 | 0.74 | CACNA1B (0.72) | NR1I2PTGS2CACNA1B | |
| SCHEMBL3486182 | 0.74 | NR1I2 (0.52) | NR1I2CACNA1B | |
| SCHEMBL8158444 | 0.73 | NR1I2 (0.49) | NR1I2CACNA1B | |
| SCHEMBL3485492 | 0.72 | NR1I2 (0.55) | NR1I2CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087446-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME CORP. | 2010-04-08 | — | — | US | disclosed |
| US-20100087446-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME CORP. | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087446-A1 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TRPV1, CACNA1S, TRPV2 | NR1I2 1761/4885PTGS2 350/4885CACNA1B 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.