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TRPV2

Transient receptor potential cation channel subfamily V member 2 · Q9Y5S1 · TRPV2 on Sugi Atlas →

4,456 patent compounds predicted against TRPV2, 3,535 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Cannabidiol Cannabidiol (SCHEMBL5485584) 0.67 3/20
Dronabinol Dronabinol (SCHEMBL9746995) 0.67 3/20
SCHEMBL8119698 SCHEMBL8119698 0.58 3/20
SCHEMBL8118114 SCHEMBL8118114 0.55 3/20
SCHEMBL8727494 SCHEMBL8727494 0.55 3/20
SCHEMBL13214122 SCHEMBL13214122 0.51 3/20
SCHEMBL13214144 SCHEMBL13214144 0.47 3/20
SCHEMBL11756581 SCHEMBL11756581 0.44 3/20
SCHEMBL11792840 SCHEMBL11792840 0.42 3/20
Cannabinol Cannabinol (SCHEMBL121085) 1.00 2/20
Cannabichromene Cannabichromene (SCHEMBL144938) 1.00 2/20
SCHEMBL2671595 SCHEMBL2671595 1.00 2/20
Cannabinol Cannabinol (SCHEMBL16061830) 0.93 2/20
SCHEMBL13214136 SCHEMBL13214136 0.93 2/20
SCHEMBL14587236 SCHEMBL14587236 0.88 2/20
SCHEMBL13214141 SCHEMBL13214141 0.81 2/20
SCHEMBL16082002 SCHEMBL16082002 0.80 2/20
SCHEMBL13214142 SCHEMBL13214142 0.78 2/20
SCHEMBL9029687 SCHEMBL9029687 0.76 2/20
SCHEMBL15827166 SCHEMBL15827166 0.71 2/20

Clinical trials — most relevant to TRPV2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
TRPV Expression in Subjects With Sensitive Skin PHASE4UNKNOWN
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls PHASE4COMPLETED
Oliceridine vs Sufentanil for Cough During Anesthesia Induction PHASE4NOT_YET_RECRUITING
The Re-Prosper HF Study PHASE2/PHASE3COMPLETED
Botulinum Toxin Injections for Oral Neuropathic Pain PHASE3COMPLETED
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC PHASE1COMPLETED
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases PHASE1COMPLETED
Do Acid Sensing Ion Channels Contribute to Heartburn? PHASE1COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3 EARLY_PHASE1COMPLETED
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1 EARLY_PHASE1RECRUITING
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures nanCOMPLETED
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin nanENROLLING_BY_INVITATION
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon. nanCOMPLETED
Dissecting the Heterogeneity of Oral Cancer Pain nanUNKNOWN
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy nanENROLLING_BY_INVITATION
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients nanACTIVE_NOT_RECRUITING
The Natural History of TRPV4 Neuropathy nanRECRUITING
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
Nutrition for Migraine Prevention nanCOMPLETED
Expressions of TRPV1 in Airway of Asthmatics nanWITHDRAWN
An Investigation Into the Mechanism of Inhalation Cough Challenge nanCOMPLETED
A Study on the Mechanism of Cough Hypersensitivity nanUNKNOWN
Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers nanRECRUITING
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor nanCOMPLETED
Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene nanRECRUITING
Effects of an Anti-TRPM8 in the Atopic Dermatitis Pruritus nanCOMPLETED
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis nanUNKNOWN
Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a TRPV2 binder may also engage these)

ProteinNameSimilarity
Q9WUD2 — 0.999 Q9WUD2 →
Q9WTR1 — 0.996 Q9WTR1 →
TRPV1 Transient receptor potential cation channel subfamily V member 1 0.993 landscape →
Q9R186 — 0.992 Q9R186 →
Q704Y3 — 0.991 Q704Y3 →
A0A1D5PXA5 — 0.989 A0A1D5PXA5 →
Q9ERZ8 — 0.989 Q9ERZ8 →
Q9XSM3 — 0.988 Q9XSM3 →
Q91WD2 — 0.988 Q91WD2 →
Q6RX08 — 0.988 Q6RX08 →
P69744 — 0.988 P69744 →
Q9EPK8 — 0.987 Q9EPK8 →
TRPV6 Transient receptor potential cation channel subfamily V member 6 0.987 landscape →
Q9JIP0 — 0.986 Q9JIP0 →
Q6R5A3 — 0.986 Q6R5A3 →
Q697L1 — 0.986 Q697L1 →
O35433 — 0.985 O35433 →
TRPV4 Transient receptor potential cation channel subfamily V member 4 0.984 landscape →
TRPV5 Transient receptor potential cation channel subfamily V member 5 0.982 landscape →
Q6XUX1 — 0.981 Q6XUX1 →
Q8K424 — 0.981 Q8K424 →
Q4VSN4 — 0.981 Q4VSN4 →
O70173 — 0.981 O70173 →
Q95KV0 — 0.981 Q95KV0 →
D3YWQ0 — 0.980 D3YWQ0 →
ABCC8 ATP-binding cassette sub-family C member 8 0.980 landscape →
Q9MYV9 — 0.980 Q9MYV9 →
Q6W3E5 — 0.980 Q6W3E5 →
Q4TVR5 — 0.980 Q4TVR5 →
Q91VB4 — 0.980 Q91VB4 →