Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | SNCA | P37840 | 2/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.44 |
| ▸ | FADS1 | O60427 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8859383 | 0.85 | SMN1; SMN2 (0.50) | LMNARAB9ANPC1TDP1CTDSP1 | |
| SCHEMBL6816710 | 0.81 | LMNA (0.57) | LMNARAB9ANPC1TDP1CTDSP1 | |
| SCHEMBL24023021 | 0.79 | LMNA (0.58) | LMNARAB9ANPC1TDP1KMT2A | |
| SCHEMBL14185647 | 0.79 | P2RX1 (0.48) | LMNARAB9ANPC1TDP1KMT2A | |
| SCHEMBL8126465 | 0.78 | HTT (0.67) | LMNAKMT2AMEN1HTTMAPT | |
| SCHEMBL6593406 | 0.78 | PTPN1 (0.69) | RAB9ANPC1TDP1KMT2AMEN1 | |
| SCHEMBL18160397 | 0.75 | LMNA (0.61) | LMNARAB9ANPC1TDP1CTDSP1 | |
| SCHEMBL18146857 | 0.75 | LMNA (0.61) | LMNARAB9ANPC1TDP1KMT2A | |
| SCHEMBL19873379 | 0.75 | LMNA (0.61) | LMNARAB9ANPC1TDP1KMT2A | |
| SCHEMBL7081255 | 0.74 | LMNA (0.49) | LMNARAB9ANPC1TDP1CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7691844-B2 | Nonpeptide substituted spirobenzoazepines as vasopressin antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2010-04-06 | — | — | US | disclosed |