Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 0.84 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.65 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9464627 | 0.94 | POLB (0.88) | POLBHTTHDAC6HDAC3HDAC4 | |
| SCHEMBL5330269 | 0.90 | HTT (0.92) | POLBHTTHDAC6HDAC3HDAC4 | |
| SCHEMBL9464308 | 0.88 | HTT (0.89) | POLBHTTHDAC6HDAC3HDAC4 | |
| SCHEMBL23080113 | 0.87 | POLB (0.76) | POLBHTTHDAC6HDAC3HDAC4 | |
| SCHEMBL1753903 | 0.86 | TDP1 (0.79) | POLBHTTHDAC6HDAC3HDAC4 | |
| SCHEMBL28257108 | 0.85 | POLB (0.74) | POLBHTTHDAC6HDAC3HDAC4 | |
| SCHEMBL4862109 | 0.85 | POLB (0.74) | POLBHTTHDAC6HDAC3HDAC4 | |
| SCHEMBL29894470 | 0.85 | POLB (0.73) | POLBHTTHDAC6HDAC3HDAC4 | |
| SCHEMBL21565076 | 0.85 | POLB (0.73) | POLBHTTHDAC6HDAC3HDAC4 | |
| SCHEMBL11252751 | 0.84 | HTT (0.78) | POLBHTTHDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106810497-B | Quinoline amide compound and the preparation method and application thereof | 中国农业大学 | 2019-10-25 | — | — | CN | claimed |
| CN-106810497-A | Quinoline amide compound and preparation method and application | 中国农业大学 | 2017-06-09 | — | — | CN | claimed |
| CN-106810497-B | Quinoline amide compound and the preparation method and application thereof | 中国农业大学 | 2019-10-25 | — | — | CN | disclosed |
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |
| CN-106810497-A | Quinoline amide compound and preparation method and application | 中国农业大学 | 2017-06-09 | — | — | CN | disclosed |
| US-20150313898-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-05 | — | — | US | disclosed |
| US-20150313898-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-05 | — | — | US | disclosed |
| US-9073896-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073896-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140113891-A1 | Compounds that inhibit human DNA ligases and methods of treating cancer | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-04-24 | — | — | US | disclosed |
| US-20140113891-A1 | Compounds that inhibit human DNA ligases and methods of treating cancer | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-04-24 | — | — | US | disclosed |
| US-8445537-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | STC.UNM (US) | 2013-05-21 | — | — | US | disclosed |
| US-8445537-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | STC.UNM (US) | 2013-05-21 | — | — | US | disclosed |
| US-20100099683-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-22 | — | — | US | disclosed |
| US-20100099683-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099683-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | LIG1, LIG4, LIG3 | POLB 17/4885HTT 1828/4885HDAC6 1061/4885 |
| US-20150313898-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | LIG1, LIG4, LIG3 | POLB 17/4885HTT 1828/4885HDAC6 1061/4885 |
| US-20140113891-A1 | Compounds that inhibit human DNA ligases and methods of treating cancer | LIG1, LIG4, LIG3 | POLB 17/4885HTT 1828/4885HDAC6 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.