Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PDE8B | O95263 | 1/20 | 0.46 |
| ▸ | SORD | Q00796 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23592772 | 0.84 | MAP4K4 (0.48) | KDM4EHSD17B10ALDH1A1TSHRMEN1 | |
| SCHEMBL13384568 | 0.81 | DYRK1A (0.42) | KDM4EHSD17B10ALDH1A1TSHRMEN1 | |
| SCHEMBL13403157 | 0.81 | KDM4E (0.54) | KDM4EHSD17B10ALDH1A1KMT2AHPGD | |
| SCHEMBL13703140 | 0.80 | KDM4E (0.46) | KDM4EHSD17B10TSHRGPBAR1HPGD | |
| SCHEMBL26047168 | 0.80 | PDE8B (0.55) | KDM4EHSD17B10ALDH1A1TSHRGPBAR1 | |
| SCHEMBL30637331 | 0.80 | KDM4E (0.50) | KDM4EHSD17B10ALDH1A1TSHRGPBAR1 | |
| SCHEMBL26051213 | 0.80 | PDE8B (0.55) | KDM4EHSD17B10ALDH1A1TSHRGPBAR1 | |
| SCHEMBL13806030 | 0.80 | SORD (0.55) | KDM4EHSD17B10ALDH1A1TSHRHPGD | |
| SCHEMBL7904079 | 0.80 | SORD (0.55) | KDM4EHSD17B10ALDH1A1TSHRHPGD | |
| SCHEMBL18228454 | 0.80 | SORD (0.55) | KDM4EHSD17B10ALDH1A1TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696210-B2 | Gonadotropin releasing hormone receptor antagonists | WYETH (US) | 2010-04-13 | — | — | US | disclosed |