Pyrimidine

Pyrimidine

SCHEMBL134034

c1c[nH]cn1.c1cncnc1

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.72
FKBP5 Q13451 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrimidine SCHEMBL16987122 0.97 ALDH1A1 (0.68) ALDH1A1FKBP5
Imidazole SCHEMBL27621126 0.88 ALDH1A1 (0.81) ALDH1A1FKBP5
Benzene SCHEMBL18279961 0.85 ALDH1A1 (0.87) ALDH1A1FKBP5
Benzene SCHEMBL29168770 0.85 ALDH1A1 (0.87) ALDH1A1FKBP5
Benzene SCHEMBL5088215 0.85 ALDH1A1 (0.87) ALDH1A1FKBP5
Imidazole SCHEMBL2635292 0.85
Imidazole SCHEMBL2684565 0.85 ALDH1A1 (1.00) ALDH1A1FKBP5
Imidazole SCHEMBL1331920 0.85
Imidazole SCHEMBL1331382 0.85
Imidazole SCHEMBL28744226 0.85 ALDH1A1 (1.00) ALDH1A1FKBP5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 196 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116217558-A GLP-1 receptor agonist, preparation method and medical application thereof 深圳信立泰药业股份有限公司 2023-06-06 CN claimed
CN-103304428-B Aminated compounds, organic illuminating element and organic light emitting apparatus comprising aminated compounds 三星显示有限公司 2018-10-19 CN claimed
CN-107001292-A Organic photovoltaic component compound and organic photovoltaic component and display element 三星SDI株式会社 2017-08-01 CN claimed
CN-105529400-A ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO LTD 2016-04-27 CN claimed
CN-103247761-A Organic light-emitting device having improved efficiency characteristics and organic light-emitting display apparatus including the same SAMSUNG DISPLAY CO LTD 2013-08-14 CN claimed
CN-102686600-A Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens TOKAI PHARMACEUTICALS 2012-09-19 CN claimed
EP-1004299-B1 VACCINE PRECURSORS, VACCINES FOR TREATING TUMORS KOYAMA SHOZO (JP) 2009-11-04 EP claimed
US-7605183-B2 Inhibitory or blocking agents of molecular generating and/or inducing functions KOYAMA SHOZO 2009-10-20 US claimed
US-20080200558-A1 Inhibitory or blocking agents of molecular generating and/or/ inducing functions KOYAMA SHOZO 2008-08-21 US claimed
EP-0780122-B1 DEPRESSANT OF FUNCTIONS DEVELOPED BY MOLECULE KOYAMA SHOZO (JP) 2006-11-22 EP claimed
EP-1414464-A2 METHOD FOR TREATING GLAUCOMA V Alteon, Inc. (US) 2004-05-06 EP claimed
EP-1406611-A2 METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS Alteon, Inc. (US) 2004-04-14 EP claimed
WO-2002096318-A2 METHOD FOR TREATING GLAUCOMA V ALTEON, INC. (US) 2002-12-05 WO claimed
WO-2002096363-A2 METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS ALTEON, INC. (US) 2002-12-05 WO claimed
US-20020165206-A1 Inhibitory or blocking agents of molecular generating and/or inducing functions KOYAMA SHOZO (JP) 2002-11-07 US claimed
US-6346551-B1 ANTIBACTERIAL, ANTIFUNGAL, ANTIVIRAL, BACTERICIDAL AND/OR STERILIZATION AGENTS, ANTICANCER DRUGS, BLOOD COAGULATION AND FIBRINOLYSIS INHIBITORS AND/OR BLOCKING AGENTS, INHIBITORY AND/OR BLOCKING AGENTS OF ANTIGEN-ANTIBODY REACTIONS KOYAMA SHOZO (JP) 2002-02-12 US claimed
US-20020009467-A1 Antigenic substance inductor, vaccine precursor, vaccine, antibody, neutralizing antibody, antitoxin, idiotype antibody and/or anti-idiotype antibody which is induced by its idiotype antibody KOYAMA SHOZO (JP) 2002-01-24 US claimed
EP-1004299-A1 ANTIGEN INDUCERS, VACCINE PRECURSORS, VACCINES, ANTIBODIES, NEUTRALIZING ANTIBODIES, ANTITOXINS, IDIOTYPIC ANTIBODIES, AND ANTI-IDIOTYPIC ANTIBODIES INDUCED BY THE IDIOTYPIC ANTIBODIES Koyama, Shozo (JP) 2000-05-31 EP claimed
CN-1162918-A Depressant of functions developed by molecule KOYAMA SHOZO (JP) 1997-10-22 CN claimed
EP-0780122-A1 DEPRESSANT OF FUNCTIONS DEVELOPED BY MOLECULE Koyama, Shozo (JP) 1997-06-25 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020165206-A1 Inhibitory or blocking agents of molecular generating and/or inducing functions CD69, TFPI, SERPINE1 ALDH1A1 2177/4885FKBP5 3266/4885
US-20020009467-A1 Antigenic substance inductor, vaccine precursor, vaccine, antibody, neutralizing antibody, antitoxin, idiotype antibody and/or anti-idiotype antibody which is induced by its idiotype antibody INHA, C3AR1, ICOS ALDH1A1 890/4885FKBP5 4500/4885
US-20080200558-A1 Inhibitory or blocking agents of molecular generating and/or/ inducing functions CD47, MCL1, BAK1 ALDH1A1 1294/4885FKBP5 2051/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.