Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 4/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | ROS1 | P08922 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13405515 | 0.90 | EML4 (0.51) | EML4ALKPOLBPIM1MAPT | |
| SCHEMBL13405504 | 0.88 | EML4 (0.52) | EML4ALKPOLBPIM1MAPT | |
| SCHEMBL13405507 | 0.88 | PIM1 (0.53) | EML4ALKPOLBPIM1MAPT | |
| SCHEMBL13405503 | 0.83 | PIM1 (0.54) | EML4ALKPOLBPIM1MAPT | |
| SCHEMBL13405512 | 0.82 | MAPT (0.61) | EML4ALKPOLBPIM1MAPT | |
| SCHEMBL13405489 | 0.81 | PIM1 (0.64) | EML4ALKPIM1MAPTMEN1 | |
| SCHEMBL13405557 | 0.74 | MAPT (0.53) | EML4ALKPIM1MAPTALDH1A1 | |
| SCHEMBL30206068 | 0.74 | EML4 (0.58) | EML4ALKMAPTMEN1KMT2A | |
| SCHEMBL29173494 | 0.74 | EML4 (0.58) | EML4ALKMAPTMEN1KMT2A | |
| SCHEMBL10126777 | 0.73 | EML4 (0.67) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-01 | — | — | US | disclosed |
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-01 | — | — | US | disclosed |
| US-7592340-B2 | Quinoxalines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592340-B2 | Quinoxalines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP4K2, MAP3K5 | EML4 2312/4885ALK 1845/4885POLB 1841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.