SCHEMBL13405643

SCHEMBL13405643

CC(=O)N1CCN(c2ccc(NC(=O)c3ccc(C#N)o3)c(N3CCC(C)CC3)c2)CC1

nearest known ligand 0.83

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 20/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13405640 0.91 CSF1R (1.00) CSF1R
SCHEMBL31157980 0.91 CSF1R (1.00) CSF1R
SCHEMBL5202289 0.89 CSF1R (1.00) CSF1R
SCHEMBL31157989 0.89 CSF1R (0.77) CSF1R
SCHEMBL3533568 0.89 CSF1R (0.77) CSF1R
SCHEMBL31157988 0.89 CSF1R (0.77) CSF1R
SCHEMBL13405642 0.88 CSF1R (0.81) CSF1R
SCHEMBL31157978 0.88 CSF1R (0.81) CSF1R
SCHEMBL13405644 0.88 CSF1R (1.00) CSF1R
SCHEMBL13405645 0.87 CSF1R (1.00) CSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7705042-B2 Class of arylamide compounds useful as inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2010-04-27 US disclosed
US-7705042-B2 Class of arylamide compounds useful as inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2010-04-27 US disclosed