Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 18/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13147874 | 0.85 | ALDH1A1 (0.49) | CSF1RALDH1A1SMN1; SMN2 | |
| SCHEMBL4980504 | 0.82 | KIT (0.54) | CSF1RKITNTRK1AXLFLT3 | |
| SCHEMBL3973680 | 0.80 | CSF1R (0.41) | CSF1RKITNTRK1AXLFLT3 | |
| SCHEMBL13439157 | 0.77 | CSF1R (0.56) | CSF1RKITNTRK1AXLFLT3 | |
| SCHEMBL13147825 | 0.77 | CSF1R (0.48) | CSF1RALDH1A1SMN1; SMN2 | |
| SCHEMBL2942364 | 0.77 | CSF1R (0.51) | CSF1RKITNTRK1AXLFLT3 | |
| SCHEMBL13405695 | 0.77 | CSF1R (0.53) | CSF1RKITNTRK1AXLFLT3 | |
| SCHEMBL3965720 | 0.75 | CSF1R (0.47) | CSF1RKITNTRK1AXLFLT3 | |
| SCHEMBL5207469 | 0.74 | CSF1R (0.60) | CSF1RKITNTRK1AXLFLT3 | |
| SCHEMBL18307002 | 0.73 | KIT (0.55) | CSF1RKITNTRK1AXLFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705042-B2 | Class of arylamide compounds useful as inhibitors of c-fms kinase | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-27 | — | — | US | disclosed |