Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 6/20 | 0.33 |
| ▸ | CNR1 | P21554 | 5/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3496696 | 0.82 | GRM2 (0.41) | RXFP1POLB | |
| SCHEMBL3495599 | 0.82 | GRM2 (0.41) | RXFP1POLB | |
| SCHEMBL4964868 | 0.80 | CYP19A1 (0.39) | CNR2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14506516 | 0.80 | RXFP1 (0.34) | RXFP1CNR2CNR1PDE1APDE1B | |
| SCHEMBL4965332 | 0.80 | CACNB4 (0.46) | KDM4EALDH1A1CYP3A4CYP2C19MEN1 | |
| SCHEMBL3494723 | 0.78 | MCHR1 (0.39) | RXFP1CNR2PDE1APDE1BPDE1C | |
| SCHEMBL3494980 | 0.78 | RXFP1 (0.36) | RXFP1CNR2CNR1PDE1APDE1B | |
| SCHEMBL14302885 | 0.78 | ALDH1A1 (0.37) | RXFP1PDE1APDE1BPDE1CKDM4E | |
| SCHEMBL4962127 | 0.77 | CACNB4 (0.36) | PDE1APDE1BPDE1CALDH1A1CYP3A4 | |
| SCHEMBL3496366 | 0.77 | HDAC1 (0.38) | PDE1APDE1BPDE1CKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7692014-B2 | Inhibitors of the HIV integrase enzyme | PFIZER, INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-7692014-B2 | Inhibitors of the HIV integrase enzyme | PFIZER, INC. (US) | 2010-04-06 | — | — | US | disclosed |