SCHEMBL13412882

SCHEMBL13412882

O=c1c2cc(F)ccc2n(-c2ccccc2)c2cc3c(=O)c4cc(F)ccc4n(-c4ccccc4)c3cc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ JAK2 O60674 1/20 0.59
▸ JAK3 P52333 1/20 0.59
▸ MAT2A P31153 1/20 0.48
▸ ATM Q13315 2/20 0.46
▸ KDM4E B2RXH2 2/20 0.46
▸ L3MBTL1 Q9Y468 2/20 0.46
▸ MPI P34949 3/20 0.45
▸ PHOSPHO1 Q8TCT1 2/20 0.45
▸ PMM2 O15305 1/20 0.45
▸ APOBEC3G Q9HC16 1/20 0.45
▸ TLR9 Q9NR96 1/20 0.45
▸ ALDH1A1 P00352 2/20 0.42
▸ GLA P06280 1/20 0.42
▸ GAA P10253 1/20 0.42
▸ HTT P42858 1/20 0.42
▸ G6PD P11413 1/20 0.42
▸ METAP2 P50579 2/20 0.41
▸ CYP1A2 P05177 1/20 0.41
▸ PDE10A Q9Y233 2/20 0.39
▸ PER2 O15055 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26596771 0.86 ATM (0.58) JAK2JAK3MAT2AATMKDM4E
SCHEMBL21666720 0.85 JAK2 (0.47) JAK2JAK3MAT2AATMKDM4E
SCHEMBL29416587 0.82 KDM4E (0.63) ATMKDM4EL3MBTL1ALDH1A1GLA
SCHEMBL85788 0.82 KDM4E (0.63) ATMKDM4EL3MBTL1ALDH1A1GLA
SCHEMBL20239634 0.81 ATM (0.67) JAK2JAK3MAT2AATMKDM4E
SCHEMBL17197529 0.80 NR3C1 (0.49) JAK2JAK3ATMKDM4EL3MBTL1
SCHEMBL21666687 0.77 KDM4E (0.61) ATMKDM4EL3MBTL1ALDH1A1GLA
SCHEMBL21666736 0.77 KDM4E (0.61) ATMKDM4EL3MBTL1ALDH1A1GLA
SCHEMBL9609410 0.77 JAK2 (0.44) JAK2JAK3MAT2AATMKDM4E
SCHEMBL19754264 0.77 JAK2 (0.52) JAK2JAK3MAT2AATMKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7683365-B2 Image pickup device FUJIFILM CORPORATION (JP) 2010-03-23 — — US disclosed
US-7683365-B2 Image pickup device FUJIFILM CORPORATION (JP) 2010-03-23 — — US disclosed
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