Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3146966 | 1.00 | KDR (0.57) | KDRABL1EGFRCSF1RPDGFRB | |
| SCHEMBL13417754 | 0.92 | KDR (0.64) | KDRABL1EGFRCSF1RPDGFRB | |
| SCHEMBL3154240 | 0.92 | KDR (0.64) | KDRABL1EGFRCSF1RPDGFRB | |
| SCHEMBL13417752 | 0.90 | RXFP1 (0.45) | KDRABL1EGFRCSF1RPDGFRB | |
| SCHEMBL3159804 | 0.90 | RXFP1 (0.45) | KDRABL1EGFRCSF1RPDGFRB | |
| SCHEMBL4973509 | 0.85 | MEN1 (0.43) | KDRFLT1MEN1ALDH1A1LMNA | |
| SCHEMBL5012043 | 0.85 | MEN1 (0.43) | KDRFLT1MEN1ALDH1A1LMNA | |
| SCHEMBL6013565 | 0.84 | KDR (0.67) | KDRABL1EGFRCSF1RPDGFRB | |
| SCHEMBL186584 | 0.84 | KDR (0.67) | KDRABL1EGFRCSF1RPDGFRB | |
| SCHEMBL6013568 | 0.83 | KDR (0.55) | KDRABL1EGFRCSF1RPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687643-B2 | Process for preparing 3,3-dimethylindolines | AMGEN INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687643-B2 | Process for preparing 3,3-dimethylindolines | AMGEN INC. (US) | 2010-03-30 | — | — | US | disclosed |