Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 20/20 | 0.79 |
| ▸ | BIRC3 | Q13489 | 8/20 | 0.79 |
| ▸ | BIRC2 | Q13490 | 8/20 | 0.79 |
| ▸ | BIRC8 | Q96P09 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1300937 | 0.89 | XIAP (1.00) | XIAPBIRC3BIRC2BIRC8 | |
| SCHEMBL1300934 | 0.89 | XIAP (1.00) | XIAPBIRC3BIRC2BIRC8 | |
| SCHEMBL13419800 | 0.89 | XIAP (1.00) | XIAPBIRC3BIRC2BIRC8 | |
| SCHEMBL12108524 | 0.89 | XIAP (1.00) | XIAPBIRC3BIRC2BIRC8 | |
| SCHEMBL31384882 | 0.89 | XIAP (1.00) | XIAPBIRC3BIRC2BIRC8 | |
| SCHEMBL12105339 | 0.89 | XIAP (1.00) | XIAPBIRC3BIRC2BIRC8 | |
| SCHEMBL12464524 | 0.89 | XIAP (1.00) | XIAPBIRC3BIRC2BIRC8 | |
| SCHEMBL19198442 | 0.89 | XIAP (1.00) | XIAPBIRC3BIRC2BIRC8 | |
| SCHEMBL13419801 | 0.88 | XIAP (0.98) | XIAPBIRC3BIRC2BIRC8 | |
| SCHEMBL9608943 | 0.87 | XIAP (0.96) | XIAPBIRC3BIRC2BIRC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674787-B2 | Conformationally constrained Smac mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-03-09 | — | — | US | disclosed |
| US-7674787-B2 | Conformationally constrained Smac mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-03-09 | — | — | US | disclosed |
| US-20080132485-A1 | Conformationally Constrained Smac Mimetics And The Uses Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-06-05 | — | — | US | disclosed |
| US-20080132485-A1 | Conformationally Constrained Smac Mimetics And The Uses Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132485-A1 | Conformationally Constrained Smac Mimetics And The Uses Thereof | BID, API5, BIRC3 | XIAP 23/4885BIRC3 3/4885BIRC2 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.