Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.54 |
| ▸ | IGF1R | P08069 | 3/20 | 0.50 |
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | PRKACG | P22612 | 1/20 | 0.46 |
| ▸ | PRKACB | P22694 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | BLK | P51451 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344744 | 0.81 | SYK (0.56) | SYKIGF1RCDK4CDK2 | |
| SCHEMBL3448943 | 0.80 | PTK2 (0.50) | SYKABL1KDRCDK5CDK2 | |
| SCHEMBL4584347 | 0.78 | IGF1R (0.48) | SYKIGF1REGFRKDRCDK2 | |
| SCHEMBL3449221 | 0.77 | KDR (0.42) | SYKIGF1RKDRCDK2AURKA | |
| SCHEMBL13420186 | 0.77 | SYK (0.52) | SYKIGF1RABL1SRCBCR | |
| SCHEMBL14140920 | 0.76 | CDK1 (0.62) | SYKIGF1RKDRCDK2 | |
| SCHEMBL5504084 | 0.75 | SYK (0.59) | SYKIGF1RABL1SRCBCR | |
| SCHEMBL3450501 | 0.75 | HDAC3 (0.44) | SYKIGF1RKDRCDK4CDK2 | |
| SCHEMBL3350947 | 0.74 | MAPK1 (0.51) | SYKIGF1REGFR | |
| SCHEMBL13169363 | 0.74 | ABL1 (0.58) | SYKABL1SRCBCREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |