Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.52 |
| ▸ | IGF1R | P08069 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 6/20 | 0.47 |
| ▸ | SRC | P12931 | 4/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
| ▸ | PRKACA | P17612 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | PRKACG | P22612 | 1/20 | 0.47 |
| ▸ | PRKACB | P22694 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.44 |
| ▸ | BLK | P51451 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3448047 | 0.86 | PTK2 (0.53) | SYKKDRCDK1CDK2ABL1 | |
| SCHEMBL3345631 | 0.82 | SYK (0.54) | SYKIGF1RKDRCDK1CDK2 | |
| SCHEMBL3448927 | 0.80 | CDK1 (0.44) | KDRCDK1CDK2PTK2CDK5 | |
| SCHEMBL13420174 | 0.77 | SYK (0.54) | SYKIGF1RKDRCDK2ABL1 | |
| SCHEMBL3450272 | 0.77 | GRM4 (0.44) | KDRCDK1CDK2PTK2ALK | |
| SCHEMBL3448567 | 0.76 | HDAC3 (0.46) | KDRCDK1CDK2PTK2ALK | |
| SCHEMBL3344725 | 0.76 | CA12 (0.50) | SYKKDRCDK1CDK2AURKA | |
| SCHEMBL5504084 | 0.73 | SYK (0.59) | SYKIGF1RKDRABL1SRC | |
| SCHEMBL13166197 | 0.72 | JAK3 (0.71) | SYKIGF1RKDRCDK1CDK2 | |
| SCHEMBL14140920 | 0.71 | CDK1 (0.62) | SYKIGF1RKDRCDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |