Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 4/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13420657 | 0.88 | JAK2 (0.44) | EGFRFGFR1HDAC3HDAC1HDAC2 | |
| SCHEMBL3448950 | 0.84 | IGF1R (0.51) | EGFRFGFR1HDAC3HDAC1HDAC2 | |
| SCHEMBL3448147 | 0.76 | IGF1R (0.49) | EGFRFGFR1HDAC3HDAC1HDAC2 | |
| SCHEMBL3345672 | 0.76 | IGF1R (0.57) | EGFRFGFR1HDAC3HDAC1HDAC2 | |
| SCHEMBL13421116 | 0.74 | HDAC3 (0.46) | EGFRFGFR1HDAC3HDAC1HDAC2 | |
| SCHEMBL23021288 | 0.74 | PLK1 (0.47) | EGFRFGFR1HDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL22999798 | 0.73 | PLK1 (0.46) | EGFRFGFR1HDAC3HDAC1HDAC2 | |
| SCHEMBL3450370 | 0.72 | IGF1R (0.53) | EGFRFGFR1HDAC3HDAC1HDAC2 | |
| SCHEMBL13420648 | 0.71 | HDAC3 (0.50) | EGFRFGFR1HDAC3HDAC1HDAC2 | |
| SCHEMBL20752152 | 0.69 | LRRK2 (0.61) | BRD4IGF1RJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |