Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.33 |
| ▸ | MERTK | Q12866 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | ULK1 | O75385 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 4/20 | 0.31 |
| ▸ | JAK1 | P23458 | 4/20 | 0.31 |
| ▸ | TYK2 | P29597 | 4/20 | 0.31 |
| ▸ | JAK3 | P52333 | 3/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13420855 | 0.90 | SYK (0.34) | EGFRTYRO3MERTKAXLFGFR1 | |
| SCHEMBL3451285 | 0.85 | AXL (0.37) | EGFRTYRO3MERTKAXLULK1 | |
| SCHEMBL3376401 | 0.84 | CSNK2A1 (0.36) | EGFRSCN9ASCN5AKCNN3SYK | |
| SCHEMBL3449151 | 0.82 | P2RX3 (0.40) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL3379025 | 0.82 | SYK (0.38) | EGFRMERTKAXLSYK | |
| SCHEMBL13312597 | 0.82 | SYK (0.38) | EGFRKCNN3SYK | |
| SCHEMBL3376905 | 0.81 | EGFR (0.39) | EGFRTYRO3MERTKAXLSCN9A | |
| SCHEMBL3450642 | 0.80 | EGFR (0.38) | EGFRFGFR1JAK2JAK1TYK2 | |
| SCHEMBL3449007 | 0.80 | EGFR (0.41) | EGFRTYRO3MERTKAXLFGFR1 | |
| SCHEMBL13421626 | 0.79 | EGFR (0.33) | EGFRAXLFGFR1SCN9AULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |