Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 15/20 | 0.39 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20504495 | 0.86 | PDE1B (0.38) | PDE1BCCR5 | |
| SCHEMBL2358590 | 0.85 | PDE1B (0.37) | PDE1BPDE10ACCR5 | |
| SCHEMBL12012887 | 0.83 | PDE1B (0.40) | PDE1BCCR5 | |
| SCHEMBL3311090 | 0.83 | PDE1B (0.40) | PDE1BPDE10ACCR5 | |
| SCHEMBL20504499 | 0.82 | MAPT (0.39) | PDE1B | |
| SCHEMBL13421525 | 0.82 | EGFR (0.38) | PDE1B | |
| SCHEMBL13421496 | 0.81 | PIK3CD (0.35) | PDE1BMAP4K3 | |
| SCHEMBL13422031 | 0.80 | SMN1; SMN2 (0.36) | PDE1BPI4KB | |
| SCHEMBL13422048 | 0.79 | CNR2 (0.37) | PDE1B | |
| SCHEMBL3723311 | 0.78 | MALT1 (0.37) | PDE1BCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042699-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |