Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.37 |
| ▸ | CNR1 | P21554 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2359107 | 0.88 | CNR1 (0.36) | CNR2CNR1MAPTMAPK1GABRG2 | |
| SCHEMBL13421525 | 0.87 | EGFR (0.38) | NPC1PIK3CAPRKDCPDE1BCCNE1 | |
| SCHEMBL13421496 | 0.83 | PIK3CD (0.35) | CYP2D6CYP2C19L3MBTL1PIK3CAALDH1A1 | |
| SCHEMBL13421283 | 0.79 | PDE1B (0.39) | PDE1B | |
| SCHEMBL20504597 | 0.77 | TYK2 (0.54) | — | |
| SCHEMBL2359901 | 0.77 | EGFR (0.36) | NPC1PIK3CAPRKDCPDE1BCCNE1 | |
| SCHEMBL13421383 | 0.74 | TYK2 (0.52) | CCNE1CDK2FLT3 | |
| SCHEMBL2358585 | 0.73 | PIK3CD (0.35) | PIK3CAPDE1B | |
| SCHEMBL13422004 | 0.68 | MEN1 (0.36) | NPC1CYP2D6CYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL20504495 | 0.67 | PDE1B (0.38) | PDE1BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042699-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |