Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13421756 | 0.88 | TYK2 (0.40) | TYK2PDE4DCCNE1CDK2FLT3 | |
| SCHEMBL13421366 | 0.84 | TYK2 (0.37) | TYK2PDE4DCCNE1CDK2FLT3 | |
| SCHEMBL13421365 | 0.84 | TYK2 (0.52) | TYK2PDE4DCCNE1CDK2FLT3 | |
| SCHEMBL13421385 | 0.80 | TYK2 (0.43) | TYK2PDE4DCCNE1CDK2FLT3 | |
| SCHEMBL13421368 | 0.79 | TYK2 (0.41) | TYK2PDE4DCCNE1CDK2FLT3 | |
| SCHEMBL3315374 | 0.77 | TYK2 (0.38) | TYK2PDE4DSTAT3IRAK4 | |
| SCHEMBL13421857 | 0.76 | TYK2 (0.49) | TYK2CCNE1CDK2FLT3STAT3 | |
| SCHEMBL13421911 | 0.73 | FYN (0.35) | TYK2PDE4DCCNE1CDK2FLT3 | |
| SCHEMBL13421386 | 0.71 | TYK2 (0.39) | TYK2PDE4DCCNE1CDK2FLT3 | |
| SCHEMBL13421592 | 0.71 | EGFR (0.34) | TYK2PDE4DCCNE1CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042699-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |