Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 9/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.35 |
| ▸ | FYN | P06241 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13421530 | 0.86 | TYK2 (0.41) | TYK2CSNK2A2PDE4DCDK2 | |
| SCHEMBL13421552 | 0.86 | MAPK14 (0.42) | TYK2PDE4D | |
| SCHEMBL13421911 | 0.85 | FYN (0.35) | TYK2CSNK2A2PDE4DFYNCCNE1 | |
| SCHEMBL13421756 | 0.84 | TYK2 (0.40) | TYK2PDE4DCCNE1CDK2FLT3 | |
| SCHEMBL13421341 | 0.80 | TYK2 (0.35) | TYK2PDE4DCCNE1CDK2FLT3 | |
| SCHEMBL13421759 | 0.80 | TYK2 (0.41) | TYK2PDE4DFYNALDH1A1CCNE1 | |
| SCHEMBL13421374 | 0.80 | TYK2 (0.41) | TYK2PDE4DFYNALDH1A1CCNE1 | |
| SCHEMBL13421554 | 0.79 | TYK2 (0.36) | TYK2CSNK2A2PDE4DFYNCCNE1 | |
| SCHEMBL13421534 | 0.78 | TYK2 (0.53) | TYK2CSNK2A2PDE4DCCNE1CDK2 | |
| SCHEMBL13422017 | 0.78 | TYK2 (0.40) | TYK2PDE4DFYNMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042699-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |