Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.47 |
| ▸ | BCR | P11274 | 5/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13421888 | 0.84 | TYK2 (0.43) | TYK2STAT3TTKPDE4D | |
| SCHEMBL13421385 | 0.82 | TYK2 (0.43) | TYK2STAT3PDE4D | |
| SCHEMBL13422017 | 0.81 | TYK2 (0.40) | TYK2STAT3PDE4DBRAF | |
| SCHEMBL3313759 | 0.80 | TYK2 (0.49) | ABL1BCRTYK2STAT3PIM1 | |
| SCHEMBL13421519 | 0.78 | TYK2 (0.49) | TYK2STAT3PDE4D | |
| SCHEMBL13421763 | 0.78 | TYK2 (0.60) | TYK2STAT3PIM1PDE4DKCNH2 | |
| SCHEMBL13421562 | 0.76 | ABL1 (0.45) | ABL1BCRPIM1BRAFIRAK4 | |
| SCHEMBL13421379 | 0.76 | TYK2 (0.56) | TYK2STAT3PIM1PDE4D | |
| SCHEMBL13421887 | 0.76 | TYK2 (0.41) | TYK2STAT3ALDH1A1RAB9APDE4D | |
| SCHEMBL13421890 | 0.76 | TYK2 (0.51) | TYK2STAT3ALDH1A1RAB9APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042699-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |