Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13422007 | 0.88 | TYK2 (0.52) | TYK2STAT3RXFP1PDE4DBRAF | |
| SCHEMBL13421374 | 0.87 | TYK2 (0.41) | TYK2PDE4DFYNMKNK1 | |
| SCHEMBL13421888 | 0.87 | TYK2 (0.43) | TYK2STAT3PDE4DFYN | |
| SCHEMBL13421385 | 0.86 | TYK2 (0.43) | TYK2STAT3PDE4D | |
| SCHEMBL13421759 | 0.85 | TYK2 (0.41) | TYK2PDE4DFYNMKNK1 | |
| SCHEMBL13421519 | 0.84 | TYK2 (0.49) | TYK2STAT3PDE4D | |
| SCHEMBL13421889 | 0.81 | ABL1 (0.47) | TYK2STAT3PDE4DBRAF | |
| SCHEMBL13421887 | 0.79 | TYK2 (0.41) | TYK2STAT3PDE4D | |
| SCHEMBL13421890 | 0.79 | TYK2 (0.51) | TYK2STAT3PDE4D | |
| SCHEMBL13421763 | 0.79 | TYK2 (0.60) | TYK2STAT3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042699-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |