Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 8/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2309014 | 0.90 | TYK2 (0.51) | TYK2STAT3TAS2R14EGLN2DYRK1A | |
| SCHEMBL13422017 | 0.88 | TYK2 (0.40) | TYK2STAT3RXFP1PDE4DBRAF | |
| SCHEMBL13421712 | 0.85 | TYK2 (0.58) | TYK2STAT3TAS2R14PDE4D | |
| SCHEMBL13641453 | 0.80 | TYK2 (0.53) | TYK2STAT3TAS2R14PDE4DCSNK2A2 | |
| SCHEMBL12013157 | 0.79 | TYK2 (0.53) | TYK2STAT3TAS2R14PDE4DCSNK2A2 | |
| SCHEMBL3313699 | 0.79 | TYK2 (0.55) | TYK2STAT3TAS2R14PDE4DCSNK2A2 | |
| SCHEMBL3314987 | 0.79 | CSNK2A2 (0.39) | TYK2STAT3EGLN2DYRK1APDE4D | |
| SCHEMBL13421374 | 0.78 | TYK2 (0.41) | TYK2PDE4D | |
| SCHEMBL3315693 | 0.77 | TYK2 (0.55) | TYK2STAT3TAS2R14PDE4DCSNK2A2 | |
| SCHEMBL12013122 | 0.77 | CSNK2A2 (0.39) | TYK2STAT3EGLN2DYRK1APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042699-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |