Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 18/20 | 0.72 |
| ▸ | EPAS1 | Q99814 | 18/20 | 0.72 |
| ▸ | EP300 | Q09472 | 2/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2561952 | 0.84 | HIF1A (1.00) | HIF1AEPAS1EP300 | |
| SCHEMBL16496923 | 0.77 | HIF1A (1.00) | HIF1AEPAS1EP300 | |
| SCHEMBL2565162 | 0.70 | HIF1A (1.00) | HIF1AEPAS1EP300 | |
| SCHEMBL2564691 | 0.69 | HIF1A (1.00) | HIF1AEPAS1EP300 | |
| SCHEMBL14916444 | 0.69 | HIF1A (1.00) | HIF1AEPAS1EP300 | |
| SCHEMBL3391430 | 0.69 | HIF1A (0.65) | HIF1AEPAS1EP300 | |
| SCHEMBL14930302 | 0.68 | HIF1A (0.77) | HIF1AEPAS1EP300 | |
| SCHEMBL15070037 | 0.67 | EP300 (1.00) | HIF1AEPAS1EP300 | |
| SCHEMBL16509890 | 0.67 | HIF1A (0.75) | HIF1AEPAS1EP300 | |
| SCHEMBL13422356 | 0.66 | EP300 (0.56) | HIF1AEPAS1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671085-B2 | Non-steroidal farnesoid X receptor modulators and methods for the use thereof | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2010-03-02 | — | — | US | disclosed |
| US-7671085-B2 | Non-steroidal farnesoid X receptor modulators and methods for the use thereof | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2010-03-02 | — | — | US | disclosed |