Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 2/20 | 0.56 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.48 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.44 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13422249 | 0.85 | EP300 (0.55) | EP300PPARDHIF1AEPAS1KDM4E | |
| SCHEMBL13422339 | 0.81 | EP300 (0.47) | EP300HIF1AEPAS1COXFA4KDM4E | |
| SCHEMBL13422354 | 0.81 | EP300 (0.54) | EP300HIF1AEPAS1KDM4ECASP1 | |
| SCHEMBL13422250 | 0.77 | NR1H4 (0.49) | EP300LPAR1LPAR5HIF1AEPAS1 | |
| SCHEMBL13422353 | 0.76 | ALDH1A1 (0.50) | EP300LPAR1HIF1AEPAS1KDM4E | |
| SCHEMBL13422377 | 0.75 | EP300 (0.50) | EP300HIF1AEPAS1COXFA4KDM4E | |
| SCHEMBL15070037 | 0.72 | EP300 (1.00) | EP300HIF1AEPAS1 | |
| SCHEMBL13422255 | 0.72 | SLC2A1 (0.44) | EP300LPAR1LPAR5HIF1AEPAS1 | |
| SCHEMBL31239009 | 0.69 | LMNA (0.46) | EP300COXFA4KDM4ECASP1CASP7 | |
| SCHEMBL5476809 | 0.69 | LMNA (0.46) | EP300COXFA4KDM4ECASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671085-B2 | Non-steroidal farnesoid X receptor modulators and methods for the use thereof | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2010-03-02 | — | — | US | disclosed |
| US-7671085-B2 | Non-steroidal farnesoid X receptor modulators and methods for the use thereof | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2010-03-02 | — | — | US | disclosed |