Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15477979 | 0.78 | MAP4K4 (0.36) | ADORA2AADORA1MAP4K4ABL1MAPK8 | |
| SCHEMBL13423899 | 0.77 | CYP1A2 (0.41) | ADORA2AADORA1MAP4K4ABL1MAPK8 | |
| SCHEMBL13423938 | 0.76 | ADORA2A (0.38) | ADORA2AADORA1MAP4K4ABL1MAPK8 | |
| SCHEMBL15477976 | 0.74 | ADORA2A (0.35) | ADORA2AADORA1MAP4K4ABL1MAPK8 | |
| SCHEMBL13424078 | 0.69 | DRD4 (0.36) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL13423946 | 0.67 | PIK3C3 (0.34) | ADORA2AADORA1MAP4K4ABL1MAPK8 | |
| SCHEMBL13423883 | 0.65 | ADORA1 (0.44) | ADORA2AADORA1MAP4K4ABL1MAPK8 | |
| SCHEMBL13423902 | 0.65 | DRD4 (0.39) | ADORA2AADORA1MAP4K4ABL1MAPK8 | |
| SCHEMBL13423903 | 0.64 | NR3C2 (0.39) | ADORA2AADORA1MAP4K4ABL1MAPK8 | |
| SCHEMBL13423905 | 0.64 | WNT3A (0.40) | ADORA2AADORA1MAP4K4ABL1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043676-A1 | TETRA-AZA-HETEROCYCLES AS PHOSPHATIDYLINOSITOL-3-KINASES (PI3-KINASES) INHIBITOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-22 | — | — | WO | disclosed |