Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K3 | Q8IVH8 | 9/20 | 0.40 |
| ▸ | GRK5 | P34947 | 4/20 | 0.40 |
| ▸ | GRK2 | P25098 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10100620 | 0.81 | FGFR1 (0.40) | MAP4K3GRK5GRK2ALKJAK2 | |
| SCHEMBL10100605 | 0.75 | MET (0.43) | GRK5GRK2JAK2METFGFR1 | |
| SCHEMBL12810998 | 0.72 | JAK2 (0.52) | MAP4K3GRK5GRK2ALKJAK2 | |
| SCHEMBL13593394 | 0.69 | MET (0.52) | MET | |
| SCHEMBL14399145 | 0.69 | MET (0.43) | MAP4K3GRK5GRK2ALKMET | |
| SCHEMBL10100602 | 0.68 | LRRK2 (0.41) | METFGFR1FGFR2FGFR3 | |
| SCHEMBL13593414 | 0.68 | JAK2 (0.46) | MAP4K3GRK5GRK2ALKJAK2 | |
| SCHEMBL13593367 | 0.67 | NEK2 (0.39) | — | |
| SCHEMBL13593432 | 0.67 | MET (0.57) | MAP4K3GRK5GRK2ALKJAK2 | |
| SCHEMBL10100785 | 0.66 | LRRK2 (0.40) | METFGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048131-A1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-29 | — | — | WO | disclosed |