SCHEMBL13424946

SCHEMBL13424946

NC1=NC=NC2C1C(I)=NN2Cc1cc2c(nc1-c1ccccc1F)CCC2

nearest known ligand 0.44

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 1/20 0.44
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL681824 0.71 PIK3CD (0.46) PIK3CDLMNATP53POLB
SCHEMBL681827 0.69 PIK3CD (0.48) PIK3CDLMNATP53POLB
SCHEMBL13425245 0.68 PIK3CD (0.41) PIK3CD
SCHEMBL682025 0.67 PIK3CD (0.72) PIK3CD
SCHEMBL13425239 0.67 PIK3CD (0.43) PIK3CD
SCHEMBL13781607 0.64 PIK3CD (0.30) PIK3CD
SCHEMBL680990 0.62 PIK3CD (0.84) PIK3CD
SCHEMBL681845 0.61 PIK3CD (1.00) PIK3CD
SCHEMBL13425078 0.55 PIK3CG (0.40) PIK3CD
SCHEMBL1385607 0.53 NPC1 (0.38) LMNATP53POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010036380-A1 HETEROCYCLIC KINASE INHIBITORS INTELLIKINE, INC. (US) 2010-04-01 WO disclosed