SCHEMBL13425239

SCHEMBL13425239

NC1=NC=NC2C1C(c1ccc(O)nc1)=NN2Cc1cc2ccccc2nc1-c1ccccc1F

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 11/20 0.43
PIK3CG P48736 7/20 0.43
PIK3C2B O00750 3/20 0.35
MBNL1 Q9NR56 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13425243 0.89 PIK3CD (0.40) PIK3CDPIK3CGPIK3C2B
SCHEMBL13425212 0.87 PIK3CG (0.48) PIK3CDPIK3CGPIK3C2B
SCHEMBL13425245 0.86 PIK3CD (0.41) PIK3CDPIK3CGPIK3C2BMBNL1
SCHEMBL13425242 0.79 PIK3CD (0.48) PIK3CDPIK3CGPIK3C2B
SCHEMBL13425246 0.79 PIK3CD (0.41) PIK3CDPIK3CGPIK3C2B
SCHEMBL13425221 0.75 PIK3CD (0.54) PIK3CDPIK3CGPIK3C2B
SCHEMBL13424948 0.74 PIK3CD (0.48) PIK3CDPIK3CG
SCHEMBL13424912 0.72 PIK3CD (0.55) PIK3CDPIK3CGPIK3C2B
SCHEMBL681783 0.72 PIK3CG (0.78) PIK3CDPIK3CGPIK3C2B
SCHEMBL13425087 0.70 PIK3C2B (0.53) PIK3CDPIK3CGPIK3C2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010036380-A1 HETEROCYCLIC KINASE INHIBITORS INTELLIKINE, INC. (US) 2010-04-01 WO disclosed