Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1342882 | 0.92 | CLK1 (0.35) | MAPTACP1ALDH1A1CLK1KMT2A | |
| SCHEMBL1343068 | 0.90 | RORC (0.38) | ALDH1A1CLK1KMT2ANPC1RAB9A | |
| SCHEMBL1342517 | 0.89 | NPC1 (0.37) | MAPTACP1ALDH1A1CLK1KMT2A | |
| SCHEMBL1342994 | 0.89 | MAPT (0.37) | MAPTACP1ALDH1A1CLK1KMT2A | |
| SCHEMBL1342956 | 0.87 | MAPT (0.36) | MAPTACP1ALDH1A1CLK1KMT2A | |
| SCHEMBL1342536 | 0.84 | MAPT (0.37) | MAPTACP1ALDH1A1CLK1KMT2A | |
| SCHEMBL5904382 | 0.82 | MAPT (0.35) | MAPTALDH1A1CLK1KMT2AMEN1 | |
| SCHEMBL1340535 | 0.81 | CLK1 (0.36) | MAPTALDH1A1CLK1KMT2AMEN1 | |
| SCHEMBL1342693 | 0.81 | NPC1 (0.39) | MAPTACP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL1341931 | 0.80 | CLK1 (0.36) | MAPTALDH1A1CLK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063081-B2 | N-(2-Phenoxyphenyl)-N'-(thiazol-2-yl)urea; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-11-22 | — | — | US | disclosed |